Antonyms of adj pernicious
2 senses of pernicious                                                  
Sense 1
baneful, deadly, pernicious, pestilent -- (exceedingly harmful)
INDIRECT (VIA noxious) -> innocuous -- (not injurious to physical or mental health)
Sense 2
insidious, pernicious, subtle -- (working or spreading in a hidden and usually injurious way; "glaucoma is an insidious disease"; "a subtle poison")
INDIRECT (VIA harmful) -> harmless -- (not causing or capable of causing harm; "harmless bacteria"; "rendered the bomb harmless")
Similarity of adj pernicious
2 senses of pernicious                                                  
Sense 1
baneful, deadly, pernicious, pestilent -- (exceedingly harmful)
       => noxious (vs. innocuous) -- (injurious to physical or mental health; "noxious chemical wastes"; "noxious ideas")
Sense 2
insidious, pernicious, subtle -- (working or spreading in a hidden and usually injurious way; "glaucoma is an insidious disease"; "a subtle poison")
       => harmful (vs. harmless) -- (causing or capable of causing harm; "too much sun is harmful to the skin"; "harmful effects of smoking")
