Antonyms of adj refreshful

1 sense of refreshful

Sense 1
bracing, brisk, fresh, refreshing, refreshful, tonic -- (imparting vitality and energy; "the bracing mountain air")

INDIRECT (VIA invigorating) -> debilitating -- (impairing the strength and vitality)

Similarity of adj refreshful

1 sense of refreshful

Sense 1
bracing, brisk, fresh, refreshing, refreshful, tonic -- (imparting vitality and energy; "the bracing mountain air")
       => invigorating (vs. debilitating) -- (imparting strength and vitality; "the invigorating mountain air")