Antonyms of verb soothe

1 of 2 senses of soothe

Sense 2
soothe -- (cause to feel better; "the medicine soothes the pain of the inflammation")
       Antonym of irritate (Sense 2)
      => irritate -- (excite to an abnormal condition, or chafe or inflame; "Aspirin irritates my stomach")

Synonyms/Hypernyms (Ordered by Estimated Frequency) of verb soothe

2 senses of soothe

Sense 1
comfort, soothe, console, solace -- (give moral or emotional strength to)

Sense 2
soothe -- (cause to feel better; "the medicine soothes the pain of the inflammation")
       => relieve, alleviate, palliate, assuage -- (provide physical relief, as from pain; "This pill will relieve your headaches")